Explore Academic Positions at Harvard Postdoctoral Fellow / Research Scientist (Ph.D.) in Human Neural Circuit Physiology Bookmark this Posting Print Preview | Apply for this Job Position Details Title Postdoctoral Fellow / Research Scientist (Ph.D.) in Human Neural Circuit Physiology School Faculty of Arts and Sciences Department/Area Stem Cell and Regenerative Biology Position Description The laboratory of Prof.
Paola Arlotta invites applications for a Ph.D.-level Postdoctoral Fellow or Research Scientist with strong expertise in systems-level electrophysiology and neural data science. The successful candidate will investigate human neural circuit physiology and neuronal dynamics in human brain organoids, with a focus on CNS disorders such as Autism Spectrum Disorder (ASD). The Arlotta Lab develops and applies human cortical
organoid models to understand principles of human cortical development and how they are perturbed in neurodevelopmental and neuropsychiatric disease. This position will center on high-throughput functional interrogation of human neural circuits and on building new experimental and analytical pipelines to link cellular and circuit phenotypes to genetic risk. Key Responsibilities · Design and execute experiments to
characterize single-cell and network-level activity in human cortical organoids and related human in vitro systems. · Lead the implementation and optimization of high-throughput functional platforms, including: o Single-unit extracellular recordings (e.g., high-density MEA systems, neural probes) o Calcium and voltage-sensitive dye imaging for large-scale population dynamics · Develop and integrate novel,
cutting-edge technologies for functional circuit analysis; independently evaluate, set up, and optimize new hardware and software platforms. · Build and maintain robust data analysis pipelines for large-scale electrophysiological and imaging datasets, including spike sorting, network analysis, and state/dynamics characterization. · Collaborate with lab members generating organoids from neurotypical and ASD-associated
genetic backgrounds to identify convergent and divergent network phenotypes. · Present results in internal and external meetings, contribute to manuscripts and grant proposals, and help mentor students and research assistants. ABOUT THE LAB We encourage applicants to read more about our scientific goals on our lab website. In addition, the Arlotta lab is actively working to become an equitable and inclusive
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