The Center for Advanced Research Technologies (CART) at the University of Rochester Medical Center (URMC) seeks an experienced and highly motivated Technical Director to lead the operations of the Cryo-Electron Microscopy (Cryo-EM) Resource Center. This individual will provide scientific, technical, and operational leadership for a growing cryo-EM facility that supports a vibrant research community. The
Cryo-EM Resource Center is in the process of installing a Thermo Fisher Scientific Glacios 3 cryo-TEM, equipped with a Selectris energy filter and Falcon 4i direct electron detector. The Technical Director will play a central role in overseeing instrument commissioning and maintenance, method development, user training, and day-to-day operational management. The successful candidate must be highly responsible,
reliable, and technically oriented, with excellent interpersonal skills. The Technical Director will have the opportunity to shape the direction of a growing cryo-EM program and play a key role in advancing cutting-edge research. This role offers a supportive, collaborative environment and excellent opportunities for career advancement. Key Responsibilities Oversee the installation, calibration,
commissioning, and ongoing optimization of the Glacios cryo-EM platform with Selectris energy filter and Falcon 4i detector, along with additional planned instrumentation acquisitions. Develop, validate, and maintain cryo-EM workflows for sample preparation, data acquisition, and data quality assessment. Collaborate effectively with the Director of CART, the Scientific Director of the Cryo-EM Resource Center, and
adjacent CART core facility leaders. Provide expert consultation to investigators on experimental design, sample suitability, data collection strategies, and optimization for cryo-EM and cryo‑ET applications. Stay current with advances in cryo-EM instrumentation, detectors, image processing software, and best practices, and implement
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