Postdoctoral Scholar-Fixed Term East Lansing, Michigan, United States Institute for Quantitative Health 40001034 Area of Interest: Research/Scientific Full Time/Part Time: Full Time (90-100%) Group: Fixed Term Academic Staff Union/Non-Union: Non-Union Faculty/Academic Staff Opening on: Oct 2 2026 Closing at: Oct 2 2028 - 23:55 EDT Salary Commensurate with Experience College Of Natural Science 1169228 Position Summary
Postdoctoral ScholarHormone Homeostasis, Drug Metabolism, and Women's HealthMichigan State UniversityDepartment of Pharmacology & ToxicologyDepartment of Biomedical EngineeringThe laboratory of Dr. Brian P. Johnson at Michigan State University invites applications for a Postdoctoral Scholar to join a multidisciplinary research team investigating how female hormonal state influences the metabolism, efficacy, and
safety of medicines throughout the body.This position is supported by the NIH Computational Modeling of Hormone Homeostasis initiative and will focus on generating experimental data needed to understand how changing endocrine states alter tissue-specific drug responses in women. The successful candidate will work closely with a collaborative team of endocrinologists, toxicologists, engineers, and computational
scientists, while leading experimental studies at the interface of women's health, drug metabolism, and endocrine biology. Research OverviewWomen experience significant physiological changes across the menstrual cycle, pregnancy, menopause, and endocrine disorders such as polycystic ovary syndrome (PCOS). These hormonal changes can alter the way medicines are metabolized and how tissues respond to therapeutic
interventions. However, the biological mechanisms underlying these differences remain poorly understood.The successful candidate will help develop human-relevant experimental models to determine how endocrine state influences drug metabolism and tissue-specific responses, with particular emphasis on:• Thyroid hormone signaling and homeostasis• Adipose tissue metabolism and energy balance• Interactions between
reproductive hormones and drug metabolism pathways• Human cell-based and microphysiological systems• Tissue-specific responses to pharmaceutical compounds under different hormonal conditions• Generation of quantitative experimental data to support predictive models of drug efficacy and safety in womenResearch in the Johnson Laboratory aims to improve our understanding of how hormonal state impacts medicine response
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