Position Summary The Califano lab, in the Department of Systems Biology at Columbia University, is seeking exceptionally qualified candidates for a Postdoctoral Research Scientist position in the laboratory. Successful candidates will possess extensive expertise in wet-lab experimentation and advanced single-cell and spatial multi-omics technologies and will participate in highly competitive research programs aimed
at producing innovative, high-impact publications. The ideal candidate will have outstanding scientific credentials, including first-author publications in leading journals and presentations at major international conferences relevant to single-cell biology, spatial genomics, systems immunology, cancer biology, stem cell biology, or related fields. We are particularly interested in candidates with demonstrated
expertise in the development and application of spatially resolved and single-cell technologies, including spatial transcriptomics, spatial ATAC-seq, multiplexed spatial proteomics, CITE-seq, Perturb-seq, CROP-seq, CRISPR-based perturbation systems, and advanced single-cell library preparation and profiling methods. Candidates with strong backgrounds in immunology, cancer biology, stem cell biology, molecular and
cellular biology, epigenetics, genetics, biomedical engineering, biochemistry, or related disciplines will be especially well suited. Experience integrating multimodal datasets—including transcriptomic, epigenomic and proteomic modalities—to define regulatory programs and cellular states within intact tissue architecture is highly desirable. Integration of quantitative analysis, high-throughput experimentation, and
technology development is a hallmark of our department and laboratory. Accordingly, the Postdoctoral Research Scientist will: Develop and apply cutting-edge spatial and single-cell multi-omics technologies to interrogate regulatory and signaling networks in complex tissue ecosystems. Define cell-state transitions and regulatory c
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