The Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain at Columbia University Irving Medical Center invite applications for a postdoctoral position in the laboratory of Dr. Natura Myeku. This NIH R01-funded project investigates the mechanisms of defective proteolysis in neurodegenerative diseases, with a strong focus
on biochemistry, proteasome biology, and protein clearance pathways in Alzheimer’s disease. Emphasis in biochemistry and in vivo biology, with opportunities to integrate high-throughput and computational approaches through close collaboration with bioinformatics experts. The successful candidate will join a multidisciplinary and collaborative research environment spanning neurodegeneration,
proteomics, transcriptomics, and cellular biology. Core Focus Areas Neurodegenerative disorders and proteasome biology Tau and amyloid pathology Innate immunity and microglia biology Single-cell/single-nucleus transcriptomics Proteomics Responsibilities Lead an NIH R01-funded project investigating proteolysis and proteasome biology in neurodegenerative disease. Apply advanced biochemical and
molecular techniques to study protein clearance and proteostasis. Perform experiments using transgenic mouse models and primary neuronal/microglial cultures. Conduct functional, biochemical, and molecular assays related to proteasome activity. Perform sequencing experiments (single-cell/single-nucleus transcriptomics, proteomics) to generate large-scale datasets. Collaborate
with the lab’s bioinformatics team on data processing and analysis. Contribute to manuscript preparation, grant applications, and interdisciplinary collaborations. Perform related duties & responsibilities for Myeku lab
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