The Oppurtunity This opportunity to join the Department of Pediatrics at the Vagelos College of Physicians and Surgeons at the rank of Postdoctoral Research Scientist is an exciting one. Columbia University Irving Medical Center, one of the nation’s foremost academic health science centers. The Department of Pediatrics at Columbia University Irving Medical Center is the top in comparison with other pediatrics
department in the NY region in NIH research funding. The primary responsibility of this role is the characterization and validation of chemical compounds identified from throughput screens ongoing for a group of genetic disorders known as lysosomal storage diseases affecting the central nervous system (e.g. metachromatic leukodystrophy and Krabbe disease). The Postdoctoral Research Scientist will work on examining
analogs synthesized from "hits" from two innovative cell-based and biochemical assays, using imaging and tandem mass spectrometry approaches. The successful candidate will have completed a PhD and/or MD and have experience in the following areas: Key Responsibilities Basic molecular biology techniques include but are not limited to, molecular cloning, transfection, infection, RNA isolation, and Northern
blotting. Perform and develop lipids and sphingolipids extraction methods from diverse matrices, with the goal of identifying novel surrogate disease markers through tandem mass spectrometry. Perform animal (mouse) experimentation, including general husbandry care, organization of murine colonies, breeding, neurobehavioral assessments with specific instrumentation, surgeries, periodic small molecule administration at
different routes, general health assessments, postmortem perfusion, organ/tissue dissection, and other animal procedures. Perform tissue cryosection and immunofluorescence staining procedures for confocal microscopy and MALDI-TOF and electron microscopy studies. Familiar with concepts of parametric and non-parametric statistics, Graph
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