Location ST. LOUIS, MO 63108

 Position Summary The Cruchaga lab at WashU Medicine has a fully funded Postdoctoral position to study Alzheimer’s disease and other neurodegenerative disease proteomics signatures. The Cruchaga lab generates and analyzes high-throughput multi-omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease,
and other dementias. The ultimate goal of the lab is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. We have pioneered in the integration of genetics with omic data to identify proteomic signatures and develop novel predictive models for Alzheimer’s, Parkinson, and Dystonia as well as to identify novel proteins and pathways implicated on disease
pathogenesis. We are currently analyzing brain, CSF and blood, multi-omic data (transcriptomics, proteomics and metabolomics), from a large collection of well-characterized samples to identify novel biomarkers and causal and druggable targets. We are seeking motivated postdocs with strong analytical skills to join our effort and generate novel insights of neurodegeneration with this unique dataset, while working in a
highly dynamic multidisciplinary and collaborative environment. The new postdoctoral fellow will join a large team, currently twenty members, which is led by three faculty members and three senior scientists. Job Description Primary Duties & Responsibilities: Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ . Lab website:
https://cruchagalab.wustl.edu/ . Research Projects : Plasma, CSF and Brain Proteomic analysis. Biomarker identification through the use of machine learning and AI approaches. Integration of proteomics with genetic data via MR, coloc and FUSION to identify causal and druggable targets. Working Conditions: This position will be located at Dr. Cruchaga’s lab in the NeuroGenomics and Informatics Center (Department of
Psychiatry) at Washington University. Work takes place in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals. Salary Range: Base pay is commensurate with experience. Applicant Special Instructions: In addition to this application, interested candidates should send a
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