Location SAINT LOUIS, MO 63110

 Position Summary The Schwartz Laboratory in the Division of Gastroenterology, Department of Medicine, at WashU Medicine in St. Louis is seeking motivated and creative scientists to join our interdisciplinary research program investigating the biology of hepatitis B virus (HBV) and the mechanisms that allow the virus to establish and maintain chronic infection. Our long-term
goal is to understand the complex interactions between HBV and its host that drive viral persistence and to use these insights to identify new strategies toward a functional cure for chronic hepatitis B, which remains a major global health challenge and an important cause of liver related morbidity and mortality. Our laboratory has a strong history of developing innovative human models of viral infection. We were
among the first groups to establish hepatitis B and hepatitis C virus infection models using stem cell-derived hepatocytes, and we have continued to combine these systems with primary human hepatocytes, CRISPR/Cas9 gene editing, and genetically distinct HBV clones to dissect the host and viral factors that determine infection and persistence. Recent work from the laboratory, published in Cell, identified a
nucleosome-level molecular switch that primes and influences HBV infection (10.1016/j.cell.2025.01.033). Job Description Primary Duties & Responsibilities: Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/ . Trains under the supervision of a faculty mentor including (but not limited to): Assists with grant preparation and reporting. Prepares and
submits papers on research. Assists in the design of research experiments. Evaluates research findings and assists in the reporting of the results. Conscientious discharge of their research responsibilities. Maintains conformity with ethical standards in research. Maintains compliance with good laboratory practice including the maintenance of adequate research records. Engages in open and timely discussion with their
mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications. Collegial conduct towards co-trainees, staff members and members of the research group. Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual
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