Neurology Postdoc - Volpicelli-Daley Bookmark this Requisition Print Preview | Apply for this Job Position Details To create a Posting, first complete the information on this screen, then click the Next button or select the page in the left hand navigation menu. Proceed through all sections completing all necessary information. To submit the Posting to Human Resources, you must go to the Posting Summary Page by
clicking on the Next button until you reach the Posting Summary Page or select Posting Summary Page from the left navigation menu. Once a summary page appears, hover your mouse over the orange Action button for a list of possible approval step options. Position Information Job Title Neurology Postdoc - Volpicelli-Daley Department Name 311500000 Neurology Chair Office School/College School of Medicine Job Description
The Volpicelli-Daley lab is seeking an Aligning Science Across Parkinson’s disease post-doctoral research fellow to study the impact of microglia on neuronal alpha-synuclein aggregate processing. This position will provide access to unique networking across the NIH and industry, career building, and presentation opportunities. Funding is currently in place for three years. Parkinson’s disease is the most common motor
neurodegenerative disorder. Formation of alpha-synuclein aggregates and brain inflammation are key hallmarks of this neurodegenerative disease. Dysfunction of lysosomes has been implicated in both of these processes and can drive PD pathogenesis. The goal of the project is to utilize induce pluripotent stem cell (iPSC) lines with PD associated gene variants differentiated into microglia and neurons. The impact on
lysosome function and pathologic alpha-synuclein processing will be determined. Key responsibilities: -Culture and differentiate microglia and neurons from iPSCs.-Perform assays for lysosome dysfunction.-Measure turnover and aggregation of alpha-synuclein.-Design experiments in collaboration with Dr. Volpicelli-Daley.-Collect and store data in an organized manner to yield clear, error-free results that are easily
analyzed and shared with the scientific community.-Maintain e-notebooks on a regular basis so that experiments can be easily replicated by others and data can be easily found. Birmingham, AL has a relatively low cost of living and minimal commute times with vibrant food scene and year-round outdoor activities. Required Qualifications -U.S. Citizenship-PhD in biomedical science-Experience with cell culture-Evidence of
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