Columbia University Irving Medical Center’s Department of Neurology invites applications for a full-time, Assistant Professor to develop a, translational research program focused on molecular mechanisms of neurodegeneration. We seek an investigator whose work centers on endolysosomal/endosomal trafficking, neuroinflammation, and therapeutic approaches (e.g., AAV-based gene therapy, small-molecule or peptide
modulators). The successful candidate will hold a medical and/or research doctoral degree, will be expected to establish an externally funded laboratory, mentor trainees, and contribute to departmental teaching and collaborative translational initiatives at and outside CUIMC (strong interactions with the proteomics, transcriptomics imaging and iPSC/core facilities encouraged). Responsibilities Establish and
lead an innovative research program investigating endolysosomal/endosomal dysfunction and neuron–glia interactions in Alzheimer’s disease, Parkinson’s disease, FTD and related disorders. Secure extramural funding (NIH, foundation, industry partnerships) to support a sustainable research program; prepare and submit competitive grant applications. Design and oversee experiments using genetic mouse models, AAV and other
gene-delivery platforms, iPSC-derived neuronal models, proteomics, and single-cell transcriptomics as appropriate. Translate basic research findings toward therapeutic strategies (e.g., vector engineering, non-invasive delivery methods, small molecule/peptide modulators) and manage collaborations with translational/industry partners. Publish high-quality manuscripts and present results at national/international
meetings; participate in patenting and technology-translation activities where appropriate. Mentor and supervise graduate students, postdoctoral fellows, research staff, and trainees; contribute to the Department’s graduate and medical student teaching program and to recruitment/training efforts. Collaborate across departments and cen
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