The Zeltser lab is looking for a motivated scientist to join their team as an Assistant Professor of Medical Sciences in Medicine at the Columbia University Medical Center (non-tenure track). The lab studies how the sympathetic nervous system regulates metabolism and how this is impacted by obesity and aging. We utilize a variety of genetically engineered mouse models, virus-based neural tracing and chemogenetic
approaches, single nuclear transcriptomics, and in vivo physiological and metabolic measurements. The ultimate goal is to identify neural circuits that regulate distinct aspects of brown fat and function and systemic metabolism. The ideal applicant will be an experienced researcher with expertise in both neuroanatomy and the neurobiology of autonomic regulation of peripheral targets and/or central regulation of
metabolic parameters. The procedures for this project require expertise in multiple advanced techniques. The experienced researcher must be able to master state-of-the-art techniques to map and manipulate sympathetic circuits regulating discrete targets in the periphery, including stereotaxic injections, viral tracing, chemogenetics and fiber photometry. In parallel, this project also involves the analysis of
physiological phenotypes in vivo, including thermogenesis, glucose uptake and lipolysis. Experience with surgical techniques in mice is essential. The applicant will be expected to lead projects independently and to train and mentor others. The applicant is also expected to make substantive contributions to the formulation and writing of manuscripts and grant applications. Interest in developing new technologies is a
plus. Responsibilities: Perform daily lab activities to carry out research projects in the lab. Perform basic neuroanatomical assays including mounting and immunohistochemical staining in sections, clearing and immunostaining in intact brains, and imaging using confocal and light sheet microscopy. Perform physiological and meta
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