The Carol and Gene Ludwig Center at the Columbia University Irving Medical Center is seeking an investigator to join a team of clinician scientists, computational biologists, statistical geneticists, cell biologists, molecular biologists and protein chemists/biophysicists. The goal of the team is to understand the fundamental biology of neurodegenerative diseases, especially Alzheimer disease. The concept is that
this understanding will form the basis for future attempts to build effective diagnostics and therapeutics. The current principal approach of this team is to identify genetic variants associated with risk, resilience or resistance to these diseases, as well as genetic variants that modulate the disease phenotype (age of onset, specific clinical or pathological features), and to uncover mechanisms of action mediated
by these variants. The successful candidate will bring complementary skills and interests that further enhance the capacity of the team to delve more deeply into disease pathobiology. Specifically, the successful candidate will apply their expertise to investigate the functional effects of genetic variants (or pools of genetic variants) that have been nominated by prior genetic studies (GWAS, WGS et cetera) and then
further filtered/enriched by computational methods. Several different potential approaches can be envisaged. Other responsibilities include: Will collaboratively engage with existing expertise in clinical research (Neurology, neuropathology, neuropsychology), statistical genetics, computational biology, cellular biology (including spatial multi-omics) and biochemistry (protein biochemistry, metabolomics, lipidomics,
neuro-inflammation); Will work especially closely with core faculty of the Carol and Gene Ludwig Center to generate ideas for new multi-PI collaborative efforts to uncover mechanisms leading to dysregulation and resilience in neurodegeneration Participate in the intellectual activities of the Carol and Gene Ludwig Center i
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